Reversing B cell aging
نویسندگان
چکیده
Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms leading to these changes are poorly understood. Recently, we have shown that these changes reflect, at least in part, homeostatic pressures imposed by long-lived B cells that accumulate with aging, and that aging in the B lineage can be reversed upon alteration of B cell homeostasis by depletion. Here we discuss homeostatic causes for B lineage immunosenescence, and the potential for its rejuvenation.
منابع مشابه
Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagneti...
متن کاملSystemic Problems: A perspective on stem cell aging and rejuvenation
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. ...
متن کاملEfficacy of platelet rich plasma (PRP) on skin rejuvenation: A systematic review
Background: With the increase in life expectancy, middle aged and elderly people comprise a substantial percentage of the population worldwide. Since aging often manifests itself in the human skin, skin rejuvenation methods have gained a lot of popularity. Current medical modalities such as botulinum toxininjection, fillers, and laser therapy can provide symptomatic relief of skin aging s...
متن کاملOxidative stress protection and vulnerability in aging: putative nutritional implications for intervention.
Research indicates that vulnerability to oxidative stress (OSV) may increase in aging, suggesting that age-related neurodegenerative diseases such as Alzheimer's disease (AD) or vascular dementia (VAD) may be superimposed upon a vulnerable neuronal environment. Determinations in cell models have suggested that the enhanced OSV may be the result of, (a) increases in membrane lipids, especially s...
متن کاملc-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.
RATIONALE Hypoxia favors stem cell quiescence, whereas normoxia is required for stem cell activation, but whether cardiac stem cell (CSC) function is regulated by the hypoxic/normoxic state of the cell is currently unknown. OBJECTIVE A balance between hypoxic and normoxic CSCs may be present in the young heart, although this homeostatic control may be disrupted with aging. Defects in tissue o...
متن کامل